The DNA methyltransferase activity of DNMT1 is vital for genomic maintenance of DNA methylation. We report here that DNMT1 function is regulated by O-GlcNAcylation. a protein modification that is sensitive to glucose levels. and that elevated O-GlcNAcylation of DNMT1 from high glucose environment leads to alterations to the epigenome. https://minidsreamers.shop/product-category/pool-accessories/