Ionizable lipid nanocarriers have made historical contribution to COVID-19 mRNA vaccines. Here. we report ionizable polymeric nanoparticles that co-deliver bi-adjuvant and neoantigen peptides for cancer immunotherapy in combination with immune checkpoint blockade (ICB). Current cancer ICB benefits only a small subset of patients. https://www.jmannino.com/best-catch-University-of-Miami-The-U-iPhone-14-Plus-Clear-Case-p36265-quick-deal/